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Updated: May 4, 2026

Identification of Kinase-substrate Pairs Using High Throughput Screening
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特定站点的竞争性激酶抑制剂使用酸盐亲和标签进行目标分析.

Wouter van Bergen1, Anneroos E Nederstigt1, Albert J R Heck1

  • 1Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, CH, The Netherlands; Netherlands Proteomics Center, Utrecht, CH, The Netherlands.

Molecular & cellular proteomics : MCP
|January 18, 2025
PubMed
概括

这项研究引入了基于特定站点的活动的蛋白质分析方法,以精确识别蛋白质激酶抑制剂标. 这种方法通过揭示与氨基酸特异性的非目标相互作用来增强药物发现.

关键词:
基于活动的蛋白质分析.化学蛋白质组学 化学蛋白质组药物目标的药物目标抑制剂选择性的抑制剂选择性这是一种激酶抑制剂 (kinase inhibitor).

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Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.
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