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在面显微症中,下分心骨质生成的最佳年龄:系统性审查和元分析

Chen Li¹, Anna Liu¹, Wei Liu¹

¹Department of Maxillofacial Surgery, Plastic Surgery Hospital and Institute, Chinese Academy of Medical Sciences, Peking Union Medical College. No. 33, Ba-Da-Chu Rd, Shi Jing Shan District, Beijing 100144, PR China.

Journal of stomatology, oral and maxillofacial surgery

|January 18, 2025

概括

在患有面显微症 (CFM) 的儿童中,下分心骨质生成 (MDO) 的最佳时间尚不清楚,因为不论年龄,复发率仍然很高. 长期监测和个性化计划对于改善结果至关重要.

科学领域:

面外科手术面外科手术
儿童整形手术儿童整形手术
整形手术整形手术整形手术

背景情况:

面显微症 (CFM) 是一种先天性疾病,影响面部发育.
部分心骨质生成 (MDO) 是一种手术程序,用于纠正CFM下部低成形.
确定MDO的最佳时间对于长期成功至关重要.

研究的目的:

系统地审查和对患有CFM的儿童中MDO的研究进行元分析.
根据长期结果和复发率,确定MDO的最佳时间.
为了比较早期 (<6岁) 和晚期 (6-16岁) MDO 程序之间的结果.

主要方法:

在PubMed,Embase,Cochrane图书馆和Web of Science的系统文献搜索到2024年9月.
包括与接受MDO和>1年随访的儿科CFM患者的研究.
主要结局:复发率 (骨架高度比);次要结局:闭口口角.

主要成果:

分析了10项涉及175名患者的研究.
综合复发率很高,年龄组之间没有显著差异 (<6岁:67.8%;6-16岁:72.5%).
复发率在五年后显著增加;封闭式声在老年儿童中复发率更高 (95.6%vs46.8%).

结论:

在CFM患者中MDO后的高复发率使最佳时间的确定变得复杂.
早期的MDO提供了心理社会效益,但长期的结果需要进一步调查.
需要个性化的治疗,精细的严重程度分级和标准化的研究方法.

关键词:

头骨面部微小症是什么部分心骨质生成部分心骨质生成操作时间表操作时间表复发率是什么意思?复发率是什么意思?

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