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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment
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以生理学为基础的药理动力学建模,以改进幼儿中波萨可纳的剂量

Paul Malik1, Paola Mian2

  • 1Ionis Pharmaceuticals Inc, Carlsbad, California.

Clinical therapeutics
|January 18, 2025
PubMed
概括

基于生理学的药理动力学 (PBPK) 建模协调了6个月至7岁儿童的波萨可纳剂量. 这种方法通过为各种配方提供特定年龄的建议来优化抗真菌治疗和预防.

关键词:
剂量 剂量 剂量 剂量侵袭性真菌感染 侵袭性真菌感染儿科 儿科 儿科基于生理学的药理动力学 (PBPK)波萨可纳 (Posaconazole) 是一种可靠的药物.

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