儿科膀组织工程:我们到底在哪里,我们下一步要去哪里?
Venkat M Ramakrishnan1, Hatim Thaker1, Gabriel-Luis Ocampo1
1Department of Urology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Journal of pediatric urology
|January 18, 2025
概括
开发一种现成的膀替代品仍然是一个挑战. 目前的膀组织工程研究重点是改善血管生成,支架,细胞来源和免疫调节,但临床相关性和生理理解是关键的差距.
科学领域:
- 再生医学是一种再生医学.
- 生物材料科学 生物材料科学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 膀组织工程的早期临床试验面临重大障碍.
- 关键的局限性包括血管生成,支架,细胞来源和免疫调节方面的挑战.
研究的目的:
- 审查早期膀组织工程试验和挑战.
- 评估15年来血管新生,支架,细胞来源和免疫调节方面的进展.
- 探索这些领域对可行的工程膀解决方案的贡献.
主要方法:
- 在PubMed搜索的研究 (2009-2024) 的叙述性综述.
- 包括在搜索期之前的早期临床试验.
主要成果:
- 分析了四项主要的临床试验.
- 突出了近20项研究,证明了血管生成,支架,细胞来源和免疫调节方面的进展.
结论:
- 目前还没有现成的膀替代品.
- 在测试临床相关疾病模型方面存在重大知识差距.
- 需要对工程组织生理学的更深入的理解.
相关概念视频
Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Development of the Oral Microbiota
The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...


