生存早产:从婴儿到青少年时期的早产个体中多系统后果的回顾性纵向研究
Ruta Morkuniene1, Ruta Levuliene2, Vilmantas Gegzna3
1Department of Anatomy, Histology and Anthropology, Institute of Biomedical Sciences, Faculty of Medicine, Vilnius University, Ciurlionio Str. 21, Vilnius, 03101, Lithuania.
BMC pediatrics
|January 18, 2025
概括
过早分娩会导致严重的健康问题,特别是在7岁时. 过早出生婴儿的低出生体重 (BW) 与整个童年期的疾病数量和复杂性更高密切相关.
科学领域:
- 儿科 儿科 儿科
- 新生儿科学 新生儿科学
- 公共卫生 公共卫生
背景情况:
- 过早生育与许多健康问题有关,但长期的多系统效应尚未完全理解.
- 了解早产儿健康结果的全部范围对于有效的管理至关重要.
研究的目的:
- 研究早产儿的长期健康轨迹.
- 分析从婴儿期到青春期的健康状况的发生率,动态和相互关系.
主要方法:
- 对417名早产儿 (2000年至2015年出生) 的回顾性纵向队列研究.
- 分析了1818个根据出生体重 (BW) 和妊娠年龄 (GA) 分类的诊断,使用ICD-10代码.
- 统计分析包括非参数测试和负二项式回归.
主要成果:
- 大多数诊断发生在7岁时;眼睛疾病,先天性形和感染是最常见的.
- 与普通人群相比,早产儿在血液,神经系统,精神和瘤疾病方面的差异更大.
- 较低的BW显著与增加的疾病数量和多样性相关,观察到独特的同时发生模式.
结论:
- 在早产个体中,疾病负担最高的发生在7岁时.
- 低出生体重是与早产儿健康复杂性增加和并发症相关的关键因素.
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