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Updated: Jun 1, 2025

Identification of Cyclin-dependent Kinase 1 Specific Phosphorylation Sites by an In Vitro Kinase Assay
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Published on: May 3, 2018

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通过CK2α介导的DUB3酸化促进了YAP1的稳定性和瘤功能

Lei Huang1, Yalei Wen2, Qin Guo3

  • 1Department of General Surgery, Guangzhou Red Cross Hospital/State Key Laboratory of Bioactive Molecules and Druggability Assessment/International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Ministry of Education (MOE) of China/College of Pharmacy, Jinan University, Guangzhou, China.

Cell death & disease
|January 18, 2025
PubMed
概括

氨酸激酶II (CK2) 通过DUB3.3调节YES相关蛋白1 (YAP1) 的稳定性. 抑制CK2会破坏YAP1的稳定,抑制癌症的进展,为卵巢和其他癌症提供新的治疗策略.

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