在 postherpetic 神经疼痛患者的模块级结构功能合的异常变化
Zihan Li1,2, Jian Jiang1,2, Xiaofeng Jiang1,2
1Department of Radiology, The First Affiliated Hospital, Nanchang University, Nanchang, 330006, China.
Scientific reports
|January 18, 2025
概括
脑神经疼痛后 (PHN) 患者的脑网络变化显示效率降低和结构功能脱,特别是在关键网络中,可能解释疼痛敏感性.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 网络科学 网络科学
背景情况:
- 术后性神经疼痛 (PHN) 是一种具有复杂神经基础的慢性疼痛疾病.
- 了解PHN中的大脑网络变化对于开发向疗法至关重要.
研究的目的:
- 研究PHN患者的功能和结构大脑网络的模块化合损失和异常变化.
- 为了将这些网络变化与临床疼痛和心理评估相关联.
主要方法:
- 收集了71名PHN患者和82名健康对照者的休息状态功能性MRI和扩散张力成像数据.
- 生成结构连接 (SC) 和功能连接 (FC) 网络,使用图形理论分析拓性质,并评估9个大脑模块之间的SC-FC合.
- 使用视觉模拟量表 (VAS),汉密尔顿焦虑量表 (HAMA) 和汉密尔顿抑郁量表 (HAMD) 进行了相关性分析.
主要成果:
- 与对照组相比,PHN患者在SC和FC网络中的全球和本地效率降低.
- 在SC和FC网络中观察到节点属性的异常 (程度,聚类系数,效率).
- 在默认模式网络 (DMN),突出网络 (SN) 和视觉网络 (VIS) 中发现了SC-FC合的显著减少.
- 损坏的图形理论指标与VAS分数呈正相关,而模块合与疾病持续时间呈负相关.
结论:
- PHN与大脑网络拓学的广泛破坏和显著的结构功能脱有关.
- 这些异常网络变化,特别是在DMN,SN和VIS中,可能会导致PHN的疼痛过敏和中心敏感化.
- 网络分析为PHN严重程度和疾病过程提供了潜在的生物标志物.
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