在第一发精神分裂症中,外周托芬-金氨酸通路功能障碍
1Affiliated Mental Health Centre & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, 310013, China.
Scientific reports
|January 18, 2025
概括
第一次精神分裂症患者表现出改变的三-金氨酸途径代谢物,神经毒性标记物增加,神经保护性标记物减少,这表明疾病发病过程中的途径失调.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生化学
- 精神病学是一个精神病学.
背景情况:
- 托 (TRP) - 氨 (KYN) 途径与精神分裂症的发病因子有关.
- 在第一发精神分裂症 (FES) 中研究TRP-KYN代谢物水平对于了解疾病机制至关重要.
研究的目的:
- 检查未服用药物的FES患者血清和尿液中的TRP-KYN代谢物水平.
- 为了将这些代谢物水平与通过正负综合征量表 (PANSS) 评估的临床症状相关联.
主要方法:
- 包括38名未经药物治疗的FES患者和43名健康对照 (HC).
- 在血清和尿液中的量化TRP-KYN代谢物.
- 使用PANSS评估了临床症状.
主要成果:
- 与HC相比,FES患者的血清中氨酸/氨酸 (QUIN/KYNA) 比率和尿液中KYN/TRP比率较高.
- 在FES患者中观察到血清中氨酸 (KYNA),氨酸 (XA) 和尿液皮科林酸 (PIC) 的降低.
- 发现尿液PIC/QUIN比率下降,尿液KYNA/KYN比率与PANSS得分之间存在负相关性.
结论:
- 患有FES的患者表现出外围TRP-KYN通路的失调.
- 神经毒性代谢物增加 (例如,QUIN/KYNA比) 和神经保护性代谢物减少表明精神分裂症病理生理学的作用.
- 这种途径失调,有利于产生神经毒性产品,可能会导致精神分裂症的发展.
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