催产素如何调节人类的行为?
Shuxia Yao1,2, Keith M Kendrick3,4
1The Center of Psychosomatic Medicine, Sichuan Provincial Center for Mental Health, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. yaoshuxia@uestc.edu.cn.
催产素 (OT) 通过神经调节间接影响社会行为,影响注意力,情绪和奖励处理. 外周效应,特别是通过迷走神经,越来越被认为对其作用至关重要.
科学领域:
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
- 行为科学 行为科学
背景情况:
- 催产素 (OT) 是一种影响社会功能的保存性神经.
- 其精确的作用机制和治疗潜力仍在研究中.
- 自闭症谱系障碍和精神分裂症中的社会功能障碍是OT治疗的潜在目标.
研究的目的:
- 审查关于OT释放刺激,功能影响和作用机制的既定发现.
- 评估外源性OT在改善自闭症和精神分裂症社会症状方面的有效性.
- 为OT对行为的神经调节作用提出一个层次模型.
主要方法:
- 对动物模型和人类研究的审查.
- 对唤起OT释放的刺激进行分析.
- 检查外源OT给药对大脑和行为的影响.
- 评估中心和外周受体的作用.
主要成果:
- OT主要通过神经调节相互作用间接影响行为.
- 外周OT效应,特别是涉及迷走神经,是显著的.
- OT调节了注意力,认知,情绪和奖励处理.
- OT促进社会理解,联系,群体凝聚力,合作和保护.
结论:
- 提出了一个等级模型,其中OT的神经调节作用促进了生存,安全和社交.
- OT促进对突出刺激的注意力,并调节社会处理.
- 了解外围机制对于治疗翻译至关重要.
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