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Updated: Jun 1, 2025

Measurement of mRNA Decay Rates in Saccharomyces cerevisiae Using rpb1-1 Strains
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在衰老中降低UPF1水平会损害无意义介导的mRNA衰变

Dahyeon Koh1, Yebin Lee1, Kyuchan Kim2

  • 1Department of Biological Sciences, Chungnam National University, Daejeon, 34134, Republic of Korea.

Communications biology
|January 18, 2025
PubMed
概括

细胞衰老通过降低UPF1蛋白水平,损害了无意义介导的mRNA衰变 (NMD). 这种下降加速了衰老和与年龄相关的疾病,因为它允许异常mRNA积累.

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