根据年龄和性别调整的CT基参考值,用于肌厚度,横截面积和放射密度
Emilia K Pesonen1, Otso Arponen2,3,4, Jaakko Niinimäki5,6
1Department of Neurosurgery, Oulu University Hospital & University of Oulu, Kajaanintie 52, Oulu, 90029, Finland. emilia.kelly@student.oulu.fi.
Scientific reports
|January 18, 2025
概括
这项研究建立了基于CT的时间肌肉厚度,面积和辐射密度的参考值,为神经和神经外科患者的萨尔科佩尼亚风险评估提供了关键的切断值.
科学领域:
- 放射学 放射学是指放射学
- 老年学是指老年学的学科.
- 神经学 神经学
背景情况:
- 传统的肌肉质量评估使用腰部CT是不切实际的神经/神经外科患者.
- 头部CT扫描提供随时可用的时间肌肉厚度 (TMT),横截面积 (TMA) 和放射密度.
- 在这些群体中评估萨尔科佩尼亚需要经过验证,可访问的方法.
研究的目的:
- 建立基于CT的TMT,TMA和放射密度的基准值,跨越几十年 (0-100年).
- 根据年龄和性别将这些值正常化.
- 根据欧洲老年人肉病工作组 (EWGSOP) 的标准,定义肉病风险截止值.
主要方法:
- 对9254名脑震荡患者头部CT扫描 (2014-2022) 的回顾性分析.
- 排除具有显著并发症的受试者;对500名受试者 (50%是男性) 的评估.
- 测量TMT,TMA和放射密度;量化观察者间/观察者内部可靠性;对与年龄相关的变化进行量化回归.
主要成果:
- 高度的测量可靠性 (对于TMT/TMA几乎完美,对于放射密度几乎完美).
- 平均值:TMT 5.2±1.9毫米,TMA 284±159毫米2,辐射密度 44.6±17.7 HU.
- 针对肌肉质量减少而建立的符合EWGSOP的切线:TMT ≤4.09 mm (M) /≤3.44 mm (F),TMA ≤166 mm2 (M) /≤156 mm2 (F),辐射密度 ≤35.5 HU (M) /≤35.2 HU (F).
结论:
- 介绍了一种基于CT的标准化,可靠的TMT和TMA测量协议.
- 量子回归模型和符合EWGSOP的截止值可以使用头部CT来轻松检测肉症.
- 能够在相关的患者群体中进行广义化的放射性萨尔科佩尼亚研究和临床应用.
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