贝塔变异复合SARS CoV-2疫苗诱导耐用交叉反应抗体对抗奥米克朗BA变异
Odile Launay1, Rachna Gupta2, Tifany Machabert3
1Assistance Publique Hôpitaux Paris (APHP), Hôpital Cochin; Université Paris Cité; Inserm CIC 1417 Cochin Pasteur, Paris, France. odile.launay@aphp.fr.
Communications medicine
|January 18, 2025
概括
与原始疫苗相比,单价Beta变体 (MVB.1.351) 疫苗产生了优越且持久的对Omicron亚变体的交叉中和抗体. 这一发现突显了其对抗不断演变的SARS-CoV-2菌株的更广泛保护的潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 病毒学 病毒学
背景情况:
- 之前的研究比较了单价Beta变体 (MVB.1.351) 和祖先疫苗 (MVD614,BNT162b2) 与AS03辅助剂的安全性和免疫性.
- 这项研究重点关注了先前接受两剂祖先mRNABNT162b2疫苗的成年人强剂反应.
研究的目的:
- 为了评估不同COVID-19助推疫苗诱导的交叉中和抗体的持久性.
- 评估对Omicron BA.1和BA.4/5亚变体的抗体反应,在增强剂后最多三个月.
主要方法:
- 一个随机试验的195名参与者的子组在基线,28天和3个月后提供了血液样本.
- 使用经过验证的伪病毒中和试验来测量抗体标位.
- 在感染和未感染的参与者中评估了抗体持久性.
主要成果:
- MVB.1.351疫苗在28天和3个月后的增强剂中显示出对Omicron BA.1和BA.4/5的最高中和抗体 (NAb) 标位.
- 在28天至3个月之间感染的参与者中,MVB.1.351和BNT162b2组都显示NAb标位增加.
- 与BNT162b2组相比,接受MVB.1.351助推剂的未感染参与者在3个月至28天内保持了较高的抗体GMT比率.
结论:
- 疫苗MVB.1.351诱导了更高和更持久的对Omicron亚变体的交叉中和抗体反应.
- 这些反应优于祖先单价疫苗和mRNA BNT162b2助推剂引起的反应.
- 这些发现表明,使用MVB.1.351助推剂增强了对流通的Omicron变种的保护.
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