地质毒素包:开源软件,用于将时空暴露与个人和人口层面的风险连接起来
Kyle P Messier1,2, David M Reif3, Skylar W Marvel3
1Predictive Toxicology Branch, Division of Translational Toxicology, National Institute of Environmental Health Sciences, 530 Davis Dr, Durham, NC, 27713, USA. kyle.messier@nih.gov.
Human genomics
|January 18, 2025
概括
该GeoTox R包提供了一种新的环境风险评估方法,通过整合地理空间数据来分析复杂的压力因素混合物及其对个人和人口健康的影响.
科学领域:
- 环境健康科学 环境健康科学
- 计算毒理学计算毒理学
- 地理空间分析是什么
背景情况:
- 从各种压力因素 (物理,化学,社会,生态,生活方式) 来描述环境风险是复杂的.
- 个人和人口的多样性在评估现实世界的暴露组合时增加了挑战.
- "GeoTox"框架提供了一个模块化方法来整合从源到结果的地理空间暴露数据.
研究的目的:
- 介绍 GeoTox 开源 R 软件包.
- 能够对受到空间参照应激剂混合物影响的分子点进行风险表征.
- 展示结合个人和人口多样性的计算工作流.
主要方法:
- 开发一个开源的R包 (GeoTox).
- 整合地理空间暴露数据.
- 为风险评估构建计算工作流程.
主要成果:
- 吉奥托克斯 (GeoTox) 促进了对人类健康不利结果的风险表征.
- 已证明适用于个人和人口层面的风险评估.
- 捕捉了环境压力因素对人类健康的复杂相互作用.
结论:
- GeoTox在环境风险表征方面取得了重大进展.
- 为GeoTox框架提供模块化软件.
- 将地理空间方法与暴露和毒理学相结合,以进行可靠的风险评估.
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