呼吸道萨尔科佩尼亚对老年肺癌患者术后病程的影响:一项回顾性研究
Dong Jae Han1, Kwon Joong Na2,3,4, Taeyoung Yun1
1Department of Thoracic and Cardiovascular Surgery, Seoul National University Hospital, 101 Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
Journal of cardiothoracic surgery
|January 18, 2025
概括
呼吸道 (RS) 没有显著影响老年患者的肺癌手术结果. 诸如男性性别和较低的一氧化碳 (DLCO) 扩散能力等因素与呼吸道并发症有更强的联系.
科学领域:
- 肺部病理学 肺部病理学
- 老年人手术是一门老年人手术.
- 在瘤学瘤学.
背景情况:
- 萨科佩尼亚越来越多地被认为是手术患者不良结果的预测因素.
- 特别是呼吸道肉症 (RS),可能会影响接受肺癌手术的患者.
- 了解RS的影响对于优化老年肺癌患者的护理至关重要.
研究的目的:
- 评估呼吸道 (RS) 与术后和长期结局之间的关联.
- 研究RS在接受肺癌手术的老年患者中的作用.
- 为了确定肺癌手术后呼吸道并发症的预测因素.
主要方法:
- 对70岁以上接受肺癌分管切除术 (2017-2019) 的患者进行了回顾性研究.
- 由低L3骨肌指数和峰值呼气流量 (PEF) 定义的RS.
- 用于共变量平衡的治疗权重 (IPTW) 的逆概率;分析了生存率和并发症率.
主要成果:
- 在509名患者中,有24.2%患有RS. 在IPTW之后,这些组在基线特征上相似.
- RS组的呼吸道并发症发生率较高 (14.5%对7.7%,p=0.041).
- 男性性别和较低的DLCO是并发症的显著预测因素;RS不是 (p=0.05). 总体或无复发生存率没有差异.
结论:
- 呼吸道 (RS) 在老年肺癌手术患者的术后和长期结果上表现出有限的影响.
- 呼吸道并发症的预测因素包括男性性别和降低的DLCO.
- 进一步的研究应该关注这些关键因素,而不是仅仅关注RS.
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