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可调节的离子释放可生物降解的纳米颗粒增强了瘤免疫疗法质灭菌的作用

Lin Liu¹, Kaiyan Huang², Xia Sun³

¹Key Laboratory of Gastrointestinal Cancer, Ministry of Education, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350122, China; Department of Nuclear Medicine, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, China; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, China.

|January 19, 2025

概括

可生物降解的无机纳米颗粒 (BINPs) 增强了癌症免疫治疗的热. 调节纳米颗粒大小改善了离子释放,导致有效的瘤治疗和免疫反应.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
免疫学免疫学免疫学

背景情况:

热是通过诱导炎症对"冷"瘤免疫疗法至关重要的.
可生物降解的无机纳米粒子 (BINPs) 可以通过离子释放触发热,但效率有限.
来自BINPs的有限离子释放限制了热和随后的免疫激活.

研究的目的:

为了合成Na3ZrF7:x%Yb3+ (NZF:x%Yb) BINPs与可调节的细胞内离子释放以增强热死.
为了研究Yb3+兴奋剂,纳米颗粒大小,离子释放和热致死之间的关系.
评估工程BINPs在促进瘤免疫疗法的有效性.

主要方法:

通过异质替代合成了一系列Na3ZrF7:x%Yb3+BINPs.
纳米粒子尺寸,降解率和细胞吸收的特征.
评估了细胞内离子释放效率,反应性氧物种 (ROS) 生成和热致死诱导.
在三阴性乳腺癌模型中评估了抗瘤疗效.

主要成果:

随着Yb3+兴奋剂的增加,NZF:x%Yb BINP的大小下降.
较小的NZF:x%Yb颗粒呈现出更高的降解率和细胞吸收.
增强的细胞内离子释放导致ROS生成和热的增加.
超小的NZF:18%Yb显示出优异的抗瘤活性和远端瘤抑制.

结论:

对BINP大小进行精确的控制对于热致死诱导免疫疗法至关重要.
可调节的BINPs细胞内离子释放效率可以显著增强热和抗瘤免疫力.
这项研究为设计BINP提供了一种新的策略,以改善癌症免疫疗法.

关键词:

可生物降解的无机纳米粒子.免疫治疗是一种免疫疗法.可调节的离子释放.热致灭 (pyroptosis) 是一种致的过程.

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