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皮克林乳液稳定由蛋衍生复制脂质纳米颗粒,用于封装和口服递送黄素

Dan Han¹, Lihua Ji², Mingzhou Lu²

¹Department of Pharmacy, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, Jiangsu, China; Nanjing Medical Center for Clinical Pharmacy, Nanjing, Jiangsu, China.

|January 19, 2025

概括

新型蛋衍生脂质纳米颗粒稳定皮克林乳液,增强营养递送和功能性食品和营养保健品的口服生物可用性.

科学领域:

食品科学与技术食品科学与技术
纳米技术纳米技术
营养学药物开发

背景情况:

对于高质量,营养和可持续的食品产品的需求日益增长.
在皮克林乳液中使用的电流稳定剂的限制.
在功能性食品中需要先进的输送系统.

研究的目的:

为皮克林乳液开发和表征新的蛋衍生复制脂质纳米颗粒 (E-rLNPs) 作为稳定剂.
为了优化从去油的蛋黄粉中提取脂质.
评估E-rLNPs在稳定皮克林乳液和提高黄素口服生物可用性的性能.

主要方法:

使用 Box-Behnken 设计的响应表面方法 (RSM) 优化脂质提取.
通过溶剂扩散方法制备E-rLNP.
由E-rLNPs稳定的皮克林乳液的形成和特征.
在各种环境压力下评估乳液稳定性.
评估黄素的保护和口服生物可用性增强.

主要成果:

优化了脂质提取过程,产生了E-rLNP.
使用E-rLNP成功形成稳定的皮克林乳液.
证明了E-rLNPs稳定乳液对环境压力的耐受性.
在黄素的保护和口服生物可用性显著改善.

结论:

来自蛋的复制脂质纳米颗粒 (E-rLNPs) 是皮克林乳液的有效稳定剂.
E-rLNP 提供了一个有前途的天然替代现有稳定剂.
这种方法推进了功能性食品和营养保健品的交付技术.

关键词:

生物可访问性生物可访问性盒子Behnken设计设计库尔库明是一种黄素.皮克林乳液是皮克林乳液中的一种.复制的脂质纳米颗粒响应表面的方法响应表面方法

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