手术后婴儿期发育结果及其相关因素:系统性审查和元分析
Fandi Hendrawan1, Ofadhani Afwan1, Patricia Alika Kurniawan1
1Faculty of Medicine, Nursing, and Public Health Universitas Gadjah Mada, Yogyakarta, Special Region of Yogyakarta, Indonesia.
Epilepsy & behavior : E&B
|January 19, 2025
概括
手术没有显著改变药物耐药 (PRE) 的婴儿的发育系数. 手术后实现无状态对于婴儿发育至关重要,尽管并不总是可能的.
科学领域:
- 儿科神经学 儿科神经学
- 发育神经科学的发展神经科学.
- 手术神经科学手术神经科学
背景情况:
- 婴儿期耐药性 (PRE) 对神经发育构成重大挑战.
- 手术是一种潜在的干预措施,但它对发育结果的影响需要彻底调查.
研究的目的:
- 系统地评估手术对患有PRE的婴儿发育系数 (DQ) 的影响.
- 在这个人群中确定与手术后发育结果相关的因素.
主要方法:
- 一个系统的审查和元分析,遵循PRISMA 2020指南.
- 在PubMed,CENTRAL和Scopus数据库中进行文献搜索;使用ROBINS-I评估偏差风险.
- 通过比较手术前和手术后的DQ来评估发育结果; meta-regression探索了影响因素.
主要成果:
- 包括10项涉及361名参与者的研究.
- 整体元分析显示,手术后的DQ没有显著变化 (MD -2.38;95% CI -5.530.78).
- 在无和无组之间没有观察到DQ变化的显著差异;没有发现显著的调节者.
结论:
- 手术可以为患有PRE的婴儿提供好处,许多婴儿的发育进展稳定.
- 手术后的无状态对于婴儿最佳发育至关重要.
- 当性病变的病变不能完全切除时,应考虑用于控制的性手术.
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