相关实验视频

Updated: Jun 1, 2025

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin
06:29

Workflow and Tools for Crystallographic Fragment Screening at the Helmholtz-Zentrum Berlin

Published on: March 3, 2021

5.4K

不同的应用程序和不同的图书馆用于晶体学碎片选.

Jessica Watt1, Mathew P Martin1, Jane A Endicott1

  • 1Newcastle University Centre for Cancer, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Newcastle Upon Tyne, NE2 4HH, UK; Cancer Research Horizons Therapeutic Innovation, Newcastle Drug Discovery Group, Translational and Clinical Research Institute, Newcastle University, Paul O'Gorman Building, Newcastle Upon Tyne, NE2 4HH, UK.

Current opinion in structural biology
|January 19, 2025
PubMed
概括

使用宏分子X射线晶体学进行碎片选是药物发现的强大工具. 该技术可用于各种应用的小分子碎片的识别和表征.

关键词:
评估药物可用性的评估.碎片图书馆是一个碎片库.基于碎片的药物发现.识别功能热点的功能热点.在X射线晶体学.

更多相关视频

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source08:35

Achieving Efficient Fragment Screening at XChem Facility at Diamond Light Source

Published on: May 29, 2021

5.0K
Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening14:04

Derivatization of Protein Crystals with I3C using Random Microseed Matrix Screening

Published on: January 16, 2021

4.6K

相关概念视频

X-ray Diffraction of Biological Samples01:10

X-ray Diffraction of Biological Samples

X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
According to Bragg's law, when X-rays strike the sample positioned on a stage, the rays are  scattered by the electron clouds around the sample atoms. The  X-ray diffraction or scattering is caused by constructive interference of the X-ray waves that reflect off the internal...
3.8K