红氧失衡驱动的表观遗传重编程和心血管功能障碍:潜在的流行药物的植物化合物
Subham Saraswata Jyotirmaya1, Suvasmita Rath2, Jagneshwar Dandapat3
1Post-graduate Department of Biotechnology, Utkal University, Bhubaneswar, 751004, Odisha, India.
概括
植物化合物可以通过向由氧化应激驱动的表观遗传变化来帮助预防和治疗心血管疾病 (CVD). 需要进一步的研究来了解它们的分子机制作为潜在的流行药.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 遗传学 遗传学 是一个
背景情况:
- 心血管疾病 (CVD) 是导致死亡的主要原因,在COVID-19后越来越多的关注.
- 表观遗传修饰 (DNA甲基化,基因组修饰,非编码RNA) 和改变的氧化还原状态显著影响心血管疾病的发展.
- 生物活性植物化合物,包括传统中医药 (TCM) 中的生物活性植物化合物,显示出调节心血管疾病相关的氧化还原平衡和表观遗传通路的潜力.
研究的目的:
- 审查与氧化应激和表观遗传改造相关的心血管疾病的风险因素.
- 评估植物化合物作为表观遗传酶 (HAT/HDAC,DNMTs) 抑制剂和miRNAs调节剂的疗效,以预防心血管疾病.
- 确定潜在的植物化合物作为新型冠状病毒药物用于心血管疾病治疗.
主要方法:
- 使用PRISMA流程方法进行系统的文献审查.
- 搜索了数据库 (PubMed,Scopus,Google Scholar) 和世卫组织/美国心脏协会的心脏病统计数据.
- 收集和分析了植物化合物,表观遗传学和心血管疾病的数据.
主要成果:
- 社会经济因素有助于氧化还原失衡,表观遗传变化和心血管疾病.
- 反氧失衡驱动表观遗传变化 (DNA甲基化,基因组修饰,非编码RNA),影响转录因子和心血管疾病发病.
- 来自草药的各种植物化合物,包括TCM,在氧化还原调节和表观遗传修饰方面表现出有效性,安全性和临床试验数据支持它们作为药物的潜力.
结论:
- 植物化合物通过向氧化还原失衡驱动的表观遗传重编程,显示出作为心血管疾病的流行药的希望.
- 进一步的研究对于阐明植物化合物介导的表观遗传重编程和CVD进展中的氧化应激管理的分子机制至关重要.
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