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从儿童的缩性自身免疫甲状腺炎中恢复:作为预后标记物的甲状腺刺激阻断抗体
Chieko Kusano1, Naoaki Hori2, Tomonobu Hasegawa3
1Department of Pediatrics, Ota Memorial Hospital, Ota, Japan, bess@fd5.so-net.ne.jp.
Hormone research in paediatrics
|January 19, 2025
概括
在患有缩性自身免疫甲状腺炎 (AAT) 的儿科患者中,甲状腺刺激阻断抗体 (TSBAb) 的消失与停止治疗相关. 监测TSBAb可以指导AAT儿童停止治疗.
科学领域:
- 儿科内分泌学 儿科内分泌学
- 自免疫性疾病 自免疫性疾病
- 甲状腺学 甲状腺学
背景情况:
- 缩性自身免疫甲状腺炎 (AAT) 是一种没有的自身免疫性甲状腺功能低下症的形式.
- 甲状腺刺激阻断抗体 (TSBAb) 在一些儿科AAT病例中被发现.
- 在成年人中,TSBAb消失与甲状腺功能恢复有关,但在儿童中尚未记录.
研究的目的:
- 报告一个具有独特抗体配置的儿科AAT病例.
- 调查TSBAb监测的潜力,以指导儿童AAT中断治疗.
主要方法:
- 一个2岁的男孩的成长迟缓和甲状腺功能低下症状被评估.
- 诊断测试显示原发性甲状腺功能低下症具有特定的抗体配置文件:对TSH受体抗体 (TRAb) 和TSBAb呈阳性,对抗甲状腺蛋白抗体 (TgAb) 和抗氧化酶抗体 (TPOAb) 呈阴性.
- 患者接受了levothyroxine,并对TSBAb水平进行了长达8年的监测.
主要成果:
- 利沃甲氧治疗使患者的生长正常化.
- 在8年内,TSBAb水平下降,导致负血清转化.
- 在10岁时成功停止了Levothyroxine治疗.
结论:
- 这一案例突出显示了一名儿科AAT患者,TRAb/TSBAb呈阳性,TgAb/TPOAb呈阴性.
- 观察到TSBAb血清转化为阴性,使治疗停止成为可能.
- 监测TSBAb可能会预测儿童AAT中成功停用levothyroxine.
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