氧化平衡得分与高血压全因死亡率之间的关系
Tianyi Ma1, Ling Wang1, Xiaorong Yan1
1Shigatse Branch, Xinqiao Hospital, Third Military Medical University, Shigatse, China.
Journal of vascular research
|January 19, 2025
概括
较高的氧化平衡得分 (OBS) 与高血压 (HTN) 患者全因死亡率的降低有关. 保持健康的生活方式和富含抗氧化剂的饮食可能会改善高血压患者的结果.
科学领域:
- 心血管健康 心血管健康
- 营养流行病学 营养流行病学
- 氧化应激的生物标志物
背景情况:
- 高血压 (HTN) 是死亡的主要风险因素.
- 氧化压力在心血管疾病的进展中起作用.
- 氧化平衡得分 (OBS) 与HTN患者的死亡率之间的关联需要进一步调查.
研究的目的:
- 探索氧化平衡得分 (OBS) 与高血压患者 (HTN) 的全因死亡率之间的关联.
主要方法:
- 利用了2007-2018年国家健康和营养检查调查 (NHANES) 对高血压患者的数据.
- 采用加权多变量考克斯回归,卡普兰-梅尔曲线和随机生存森林 (RSF) 分析.
- 将NHANES数据与全国死亡指数记录连接到2019年12月31日,以确定全因死亡率.
主要成果:
- 分析了一组13,130名参与者,其中2,132人死亡.
- 较高的OBS与HTN患者全因死亡风险较低显著相关 (HR = 0.77,95%CI:0.65-0.91).
- 这种关联在包括男性,患有/没有慢性脏病的人以及患有心血管疾病的人在内的子组中持续存在.
结论:
- 升高的OBS与高血压患者全因死亡率的降低有关.
- 促进健康的生活方式和富含抗氧化剂的饮食可能会改善高血压患者的预后.
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