骨肌肉脂肪,冠状动脉微血管功能障碍,以及不良的心血管结果
Ana Carolina do A H Souza1, Amelie S Troschel2,3, Jan P Marquardt2
1Cardiovascular Imaging Program, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115, USA.
增加骨肌脂肪透 (IMAT) 与冠状动脉微血管功能障碍 (CMD) 和主要心血管不良事件 (MACE) 相关,独立于BMI. 这突出了一个新的心脏代谢风险表型.
科学领域:
- 心脏病学 心脏病学
- 代谢健康 代谢健康
- 影像科学 影像科学
背景情况:
- 骨肌肉 (SM) 脂肪透 (肌肉间脂肪组织 - IMAT) 影响肌肉质量和炎症,是心脏代谢疾病的关键因素.
- 冠状动脉流量储备 (CFR) 是冠状动脉微血管功能障碍 (CMD) 的衡量标准,与BMI和炎症相关,并预测心血管不良事件.
- 仍然不清楚SM质量,CMD和心血管结局之间的相互作用.
研究的目的:
- 调查SM脂肪透 (IMAT),CMD (通过CFR测量) 和主要不良心血管事件 (MACE) 之间的关联.
- 确定IMAT和CMD是否识别出独立于身体质量指数 (BMI) 的独特心脏代谢风险表型.
主要方法:
- 669名患者接受了冠状动脉疾病评估,具有正常的输液和射出分数,在6年内对MACE进行了跟踪.
- 冠状动脉流量储备 (CFR) 使用心脏应激正子发射断层扫描计算.
- 肌肉间脂肪组织 (IMAT),皮下脂肪组织 (SAT) 和SM区域通过PET扫描的CT减弱校正量化.
主要成果:
- 降低SM和增加IMAT,但不是BMI或SAT,独立地与降低CFR相关.
- 较高的IMAT和较低的CFR与MACE风险增加有关.
- 增加的IMAT,定义为脂肪肌肉分数,独立增加了CMD和MACE风险的几率.
- 根据CMD和IMAT之间的显著相互作用,在患有这两种疾病的患者中,MACE风险最高.
结论:
- 增加的IMAT与CMD和不良心血管结果独立相关,无论BMI如何.
- 结合CMD和SM脂肪透,可以发现一种新的,高风险的心脏代谢表型.
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