探索细胞指数在性结肠炎诊断中的有用性
Julio César Moreno Alfonso1, Sharom Barbosa-Velásquez2, Carlos Delgado-Miguel3
1Department of Pediatric Surgery, Hospital Universitario de Navarra, Pamplona, Navarra, Spain; Doctoral School, Universidad Pública de Navarra (UPNA), Pamplona, Navarra, Spain.
单细胞-淋巴细胞比率 (MLR) 在内镜检查前对儿童的性结肠炎 (UC) 诊断具有前景. 这种细胞指数具有高灵敏度和负预测值,有助于早期发现UC.
科学领域:
- 儿科胃肠病学 儿科胃肠病学
- 炎症性肠道疾病诊断 诊断 炎症性肠道疾病诊断
- 血液学生物标志物 血液学生物标志物
背景情况:
- 儿童的性结肠炎 (UC) 诊断通常需要像结肠镜等侵入性手术.
- 确定可靠的非侵入性生物标志物用于早期UC检测对于及时管理至关重要.
- 反映免疫细胞平衡的细胞指数正在被探索为潜在的诊断工具.
研究的目的:
- 评估特定细胞指数的诊断效用,包括血小板-淋巴细胞比率 (PLR),中性粒细胞-淋巴细胞比率 (NLR) 和单细胞-淋巴细胞比率 (MLR),在儿童患者怀疑性结肠炎.
- 为了比较这些指数的灵敏度,特异性和预测值,在区分UC与其他条件时.
主要方法:
- 一项诊断研究包括儿童患者 (<15岁) 在2015-2022年期间因疑似炎症性肠病接受内镜检查.
- 分析了正常活检和确认UC诊断的患者.
- 用ROC曲线分析评估PLR,NLR和MLR的诊断性能,以确定灵敏度,特异性和赔率比率.
主要成果:
- 这项研究包括26名患者 (14例正常活检,12例UC).
- 单细胞-淋巴细胞比率 (MLR) 和PLR在UC患者中显著增加 (p<0.05).
- MLR表现出最高的诊断性能,灵敏度为70%,特异性为71%,赔率比为11 (AUC=0.735).
结论:
- 单细胞-淋巴细胞比率 (MLR) 显示出作为儿科患者性结肠炎的前内学生物标志物的显著潜力.
- MLR的高灵敏度和负预测值表明其在UC的初始诊断工作中具有实用性.
- 进一步的研究可能会支持MLR在优先考虑怀疑UC的内镜手术方面的作用.
更多相关视频
07:38Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
Published on: September 13, 2016
07:05Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
Published on: May 12, 2019
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Serum Laboratory Studies, Stool Test, Breath Test
Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
Drugs for Treatment of Ulcerative Colitis in IBD
