ExerGeneDB:一个体育运动调节的差异性基因表达数据库
Ling Pan1, Songwei Ai1, Xiaohui Shi1
1Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Science, Shanghai University, Shanghai 200444, China; Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.
Journal of sport and health science
|January 19, 2025
概括
我们创建了ExerGeneDB,这是运动调节基因的综合数据库. 它整合了各种数据集和临床因素,以帮助研究人员理解炼.
科学领域:
- 分子生物学和基因组学
- 运动科学和生理学
- 生物信息学和数据科学
背景情况:
- 运动会在多个器官和组织中引起复杂的分子变化.
- 这些变化受到运动参数 (强度,频率,模式,持续时间) 和临床特征 (性别,年龄,BMI) 的影响.
- 一个全面的理解需要整合不同的数据类型和临床信息.
研究的目的:
- 为运动调节基因开发一个集中的,交互式数据库.
- 为研究分子对运动反应的研究人员提供全面的资源.
- 为了促进基因表达模式的分析,考虑各种运动方案和临床因素.
主要方法:
- 综合公开可用的与运动相关的测序数据集.
- 对不同类型的数据进行统一的质量控制和预处理.
- 进行差异性基因表达分析,结合临床数据 (性别,年龄,BMI).
主要成果:
- 汇集了一个大型数据集,包括1692个动物和4492个人类样本.
- 包含来自众多组织和器官 (如骨肌肉,血液,脂肪组织,大脑,心脏) 的数据.
- 包括各种测序技术:散装RNA-seq,微阵列和单细胞RNA-seq,涵盖编码和非编码RNA.
结论:
- ExerGeneDB收集并重新分析与运动相关的数据,强调临床信息.
- 该数据库为探索运动调节基因提供了一个交互式平台.
- 在https://exergenedb.com上访问ExerGeneDB,以支持运动生物学研究.
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