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相关概念视频

What is Gene Expression?01:42

What is Gene Expression?

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Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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ExerGeneDB:一个体育运动调节的差异性基因表达数据库.

Ling Pan1, Songwei Ai1, Xiaohui Shi1

  • 1Institute of Cardiovascular Sciences, Shanghai Engineering Research Center of Organ Repair, Joint International Research Laboratory of Biomaterials and Biotechnology in Organ Repair (Ministry of Education), School of Life Science, Shanghai University, Shanghai 200444, China; Cardiac Regeneration and Ageing Lab, Institute of Geriatrics (Shanghai University), Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of Medicine, Shanghai University, Nantong 226011, China.

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|January 19, 2025
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概括
此摘要是机器生成的。

我们创建了ExerGeneDB,这是运动调节基因的综合数据库. 它整合了各种数据集和临床因素,以帮助研究人员理解炼.

关键词:
练习数据库 练习数据库运动调节的差异基因身体炼是一种体力炼.

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科学领域:

  • 分子生物学和基因组学
  • 运动科学和生理学
  • 生物信息学和数据科学

背景情况:

  • 运动会在多个器官和组织中引起复杂的分子变化.
  • 这些变化受到运动参数 (强度,频率,模式,持续时间) 和临床特征 (性别,年龄,BMI) 的影响.
  • 一个全面的理解需要整合不同的数据类型和临床信息.

研究的目的:

  • 为运动调节基因开发一个集中的,交互式数据库.
  • 为研究分子对运动反应的研究人员提供全面的资源.
  • 为了促进基因表达模式的分析,考虑各种运动方案和临床因素.

主要方法:

  • 综合公开可用的与运动相关的测序数据集.
  • 对不同类型的数据进行统一的质量控制和预处理.
  • 进行差异性基因表达分析,结合临床数据 (性别,年龄,BMI).

主要成果:

  • 汇集了一个大型数据集,包括1692个动物和4492个人类样本.
  • 包含来自众多组织和器官 (如骨肌肉,血液,脂肪组织,大脑,心脏) 的数据.
  • 包括各种测序技术:散装RNA-seq,微阵列和单细胞RNA-seq,涵盖编码和非编码RNA.

结论:

  • ExerGeneDB收集并重新分析与运动相关的数据,强调临床信息.
  • 该数据库为探索运动调节基因提供了一个交互式平台.
  • 在https://exergenedb.com上访问ExerGeneDB,以支持运动生物学研究.