空瓶,风险上升:关于心理治疗药物耗尽和自杀触发因素的案例交叉研究
Austin Porter1, Allen M Smith2, Srinivasa B Gokarakonda3
1Fay W. Boozman College of Public Health, Department of Health Policy and Management, University of Arkansas for Medical Sciences, Little Rock, AR 72205, United States of America; Arkansas Department of Health, Little Rock, AR 72205, United States of America.
耗尽心理治疗药物与增加自杀风险有关. 密切监测药物供应对于患有心理健康障碍的人来说至关重要.
科学领域:
- 精神病学和行为科学
- 公共卫生 公共卫生
- 药学流行病学 药学流行病学
背景情况:
- 心理治疗药物对于管理心理健康障碍和降低自杀风险至关重要.
- 药物消耗对自杀风险的影响仍未得到充分研究.
研究的目的:
- 调查心理治疗药物供应耗尽与自杀之间的时间关联.
- 分析自杀前期药物消耗的几率.
主要方法:
- 一个案例交叉研究设计,利用阿肯色州 (2013-2021) 的药房和医疗索赔数据.
- 识别自杀死亡者和估计药物耗尽日期,使用药物数据.
- 使用条件后勤回归,比较7天危险窗口期间的药物消耗与前11周的对照.
主要成果:
- 17.0%的自杀者在危险窗口中耗尽了至少一种心理治疗药物.
- 与对照期相比,在危险窗口期间观察到心理治疗药物耗尽的可能性增加了46% (AOR: 1.46; p=0.0001).
结论:
- 在耗尽心理治疗药物和自杀之间存在显著的时间关系.
- 密切监测药物供应对于那些被处方心理治疗药物的患者来说至关重要,以减轻自杀风险.
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