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Updated: Jun 1, 2025

Utilizing Functional Genomics Screening to Identify Potentially Novel Drug Targets in Cancer Cell Spheroid Cultures
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FOXM1通过向肝细胞癌中的SPINK1并影响p53通路,促进恶性生物行为和代谢重编程

Xu Ding1, Jinjun Shi2, Zhengqing Lei3

  • 1School of Medicine, Southeast University, Naanjing 210009, Jiangsu, PR China.

Biochimica et biophysica acta. Molecular basis of disease
|January 19, 2025
PubMed
概括

这项研究揭示了一个关键的FOXM1-SPINK1轴驱动肝癌进展. FOXM1在转录上调节SPINK1,促进瘤生长,转移,并影响p53通路,提供潜在的治疗点.

关键词:
在FOXM1上.在HCC中,HCC是HCC.这就是SPINK1的原因.转录法规 转录法规通过p53路径.

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