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相关概念视频

Development of Immunocompetence01:22

Development of Immunocompetence

283
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
283
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

948
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
948
Immunological Memory01:23

Immunological Memory

523
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
523
B Cell Activation and Differentiation01:24

B Cell Activation and Differentiation

1.6K
The adaptive immune response, a sophisticated defense mechanism, relies on the activation and differentiation of B lymphocytes, or B cells. These processes enable our bodies to mount a tailored response against specific pathogens such as bacteria, free virus particles, toxins, and parasites.
When naive B cells encounter a specific antigen that can bind to the B cell receptor (BCR) on their surface, they undergo sensitization to respond to the antigen's presence. Sensitization begins with...
1.6K
T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

646
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
646
Vaccinations01:51

Vaccinations

44.0K
Overview
44.0K

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相关实验视频

Updated: Jun 1, 2025

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

Published on: August 17, 2022

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在母体免疫激活后进行序列学习.

Tallulah-May R Patterson1, Rebecca E A Dunn1, David K Bilkey1

  • 1Department of Psychology, University of Otago, Dunedin 9016, New Zealand.

Behavioural brain research
|January 19, 2025
PubMed
概括
此摘要是机器生成的。

在老鼠中,母体免疫激活 (MIA) 没有影响简单序列学习,但显示出行为不灵活性和改变习惯性. 这些发现表明MIA可能会影响与精神分裂症相关的认知灵活性.

关键词:
行为学 行为学一个MIA是MIA,一个MIA是MIA.认可 承认 认可反向学习是一种反向学习.精神分裂症是一种精神分裂症.序列 序列是指一个序列.

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

Published on: May 21, 2015

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相关实验视频

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Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring
09:09

Generating a Reproducible Model of Mid-Gestational Maternal Immune Activation using PolyI:C to Study Susceptibility and Resilience in Offspring

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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C
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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic PolyI:C

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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface
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Isolation of Leukocytes from the Murine Tissues at the Maternal-Fetal Interface

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科学领域:

  • 神经科学是一个神经科学.
  • 发展心理学 发展心理学
  • 精神病学是一个精神病学.

背景情况:

  • 孕产妇免疫激活 (MIA) 与精神分裂症风险有关.
  • 精神分裂症与顺序记忆和刺激顺序回忆的缺陷有关.

研究的目的:

  • 调查MIA是否诱导大鼠的序列学习和对象位置近期记忆的缺陷.
  • 评估MIA暴露动物的认知灵活性和习惯过程.

主要方法:

  • 老鼠接受了MIA或是对照.
  • 实验1:在一个有提示的鼻任务中评估序列学习.
  • 实验2:评估空间位置 (TOSL) 的时间排序和习惯.

主要成果:

  • MIA老鼠学习结构化的序列类似于对照,但在序列发生变化时表现出较少的行为灵活性.
  • 与对照组相比,MIA老鼠在TOSL任务中没有表现出明显的新奇性偏好.
  • 在TOSL任务中,MIA老鼠显示出随着时间的推移而改变的探索模式和习惯.

结论:

  • MIA不会影响基本的序列学习,但会影响认知灵活性和习惯性.
  • MIA动物的行为变化可能与改变的习惯率或响应不灵活性有关.
  • 研究结果提供了对潜在的神经发育机制的洞察力,这些机制是精神分裂症风险的基础.