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Updated: Jun 1, 2025

RNA Next-Generation Sequencing and a Bioinformatics Pipeline to Identify Expressed LINE-1s at the Locus-Specific Level
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通过p53调节LINE1逆转移素衍生的R循环

Pratyashaa Paul1, Arun Kumar1, Ankita Subhadarsani Parida1

  • 1Department of Biological Sciences, Indian Institute of Science Education and Research Berhampur, Berhampur, Odisha, India.

The Journal of biological chemistry
|January 19, 2025
PubMed
概括

瘤抑制剂p53通过沉默长间隔核元素1 (LINE1) 转位子来防止基因组的不稳定. 它抑制了RNA-DNA混合体 (R-循环) 的形成,并与基因组甲基转移酶一起工作以抑制L1激活.

关键词:
造成的DNA损伤是DNA损伤.L1/LINE1 在线阅读在R-Loop中使用.这是RNA-DNA混合体.ci R-循环的循环.基因组的不稳定性长非编码RNA是什么意思在 p53 里,p53 是一个 p53 的类型.反向转录是一种反向转录.跨 R 循环的循环.

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