一项前性自我控制研究,研究了与长时间接触视频显示终端相关的眼睛表面和结膜转录形状的变化
Ling Li1, Xinhao Zhu2, Weihao Xu2
1Ningbo Eye Hospital, Wenzhou Medical University, Ningbo, 315042, China; National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou, 325027, China.
The ocular surface
|January 19, 2025
概括
长时间使用视频显示终端 (VDT) 会显著恶化干眼症状和症状,增加干眼诊断率并导致眼睛表面炎症. 这凸显了长时间屏幕对眼睛健康的负面影响.
科学领域:
- 眼科医生 眼科 眼科
- 眼睛表面疾病 眼睛表面疾病
- 数字健康数字健康
背景情况:
- 数字设备在现代生活中无处不在.
- 长时间使用视频显示终端 (VDT) 可能会影响眼睛表面的健康.
- 了解VDT对眼睛稳态的影响至关重要.
研究的目的:
- 调查延长视频显示终端 (VDT) 暴露对眼表表面平衡的影响.
- 量化干眼症状和与增加VDT使用相关的临床症状的变化.
主要方法:
- 30名参与者将VDT的使用量减少到一周的每天3小时,然后增加到三周的每天>8小时.
- 每周的评估包括眼睛表面疾病指数 (OSDI) 问卷和临床眼科检查.
- 进行了眼和梅博米腺评估以及眼表面转录基因分析.
主要成果:
- 随着长期使用VDT,干眼诊断从6.67%增加到51.67%.
- 观察到OSDI得分显著恶化,眼膜稳定性降低 (FBUT),眼睛染色增加 (CFS,LCjs).
- 转录组分析显示了炎症和激素基因表达变化,MUC5AC和TFF1基因表达与症状严重程度相关.
结论:
- 强烈和长时间的VDT暴露显著损害了眼睛表面的恒常性.
- 增加屏幕时间会导致眼睛表面症状,迹象和基因表达的有害变化.
- 这些发现强调了需要采取策略来缓解VDT诱导的眼睛表面疾病.
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