儿童食品蛋白质诱导肠球炎综合征复发的严重性趋势
Mariannita Gelsomino1, Simona Barni2, Francesco Mastellone1
1Pediatric Allergy Unit, Department of Life Sciences and Public Health, Fondazione Policlinico Universitario A Gemelli IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
由于严重反应的高风险,对食物蛋白诱导肠道炎综合征 (FPIES) 引发的触发性食物的家庭再引入是不安全的. 一些牛奶FPIES患者可能会面临门诊挑战,他们有紧急转移计划.
科学领域:
- 儿科过敏和免疫学
- 胃肠病学 胃肠病学
- 临床营养学 临床营养学
背景情况:
- 食品蛋白诱导肠球炎综合征 (FPIES) 的重新引入需要医院口服食品挑战 (OFC),导致延迟和资源紧张.
- 目前对FPIES的OFC协议有助于显著的医疗保健成本和漫长的等待时间.
研究的目的:
- 为了评估个别儿科患者中急性FPIES反应严重性的趋势.
- 确定导致FPIES的食物在门诊或家庭重新引入的可行性.
主要方法:
- 两家意大利过敏诊所对202名被诊断患有急性FPIES的儿科患者进行了回顾性分析.
- 评估了严重反应的风险,并确定了家庭/门诊恢复的5%或更低的可接受门.
主要成果:
- 11.4%的患者随着时间的推移经历了反应严重程度 (轻度至严重程度) 的增加.
- 没有人口或时间因素预测严重反应的风险增加.
- 5.5%的牛奶FPIES患者最初有轻度反应,后来发生严重发作.
结论:
- 由于严重不良反应的风险>5%,不建议为FPIES使用Home OFC.
- 对于初始轻度反应的牛奶FPIES患者,可以考虑门诊OFC,前提是可提供快速紧急转移.
更多相关视频
09:36Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
Published on: July 28, 2022
08:53Recurrent Escherichia coli Urinary Tract Infection Triggered by Gardnerella vaginalis Bladder Exposure in Mice
Published on: December 4, 2020
相关概念视频
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Overview of Protein Metabolism
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Conditioned Taste Aversion
A notable characteristic of conditioned taste aversion is that it often requires only a single...
