使用美国国家健康和营养检查调查数据,对甲状腺功能进行全暴露组关联研究
Jiyun Lee1, Hyuna Jang1, Elizabeth N Pearce2
1Department of Environmental Science, Baylor University, Waco, TX, USA.
Environmental research
|January 19, 2025
概括
这项研究使用NHANES数据调查了化学混合物暴露和甲状腺功能. 它在青少年和成年人中发现农药,金属和改变的甲状腺激素之间的关联,突出显示了环境化学物质对内分泌健康的影响.
科学领域:
- 环境流行病学环境流行病学
- 内分泌学 在内分泌学.
- 毒理学 毒理学 毒理学
背景情况:
- 之前的研究经常研究单一的化学物质暴露,忽视了复杂的环境混合物.
- 甲状腺功能对整体健康至关重要,可以受到环境因素的影响.
- 了解化学混合物的影响对于公共卫生和风险评估至关重要.
研究的目的:
- 探索数百种化学物质暴露与甲状腺功能之间的关联,使用全暴露组关联研究 (ExWAS) 方法.
- 研究化学混合物对青少年和成人甲状腺功能的影响.
- 为了确定与甲状腺功能相关的特定化学生物标志物.
主要方法:
- 利用了2007-2012年国家健康和营养检查调查 (NHANES) 数据 (N=9,082).
- 采用多重回归和贝叶斯群权重定量总和 (BGWQS) 回归来分析单一和混合化学物质暴露.
- 测量甲状腺功能测试 (T3,T4,TSH) 和化学生物标志物度.
主要成果:
- 在青少年和成年人中分别确定了44个和67个与甲状腺功能相关的生物标志物.
- 农药,NIS抑制剂和金属与两年龄组的甲状腺激素或TSH变化有关.
- 挥发性有机化合物与青少年的T4降低有关;芬醇和类与成人的TSH降低有关.
结论:
- 这项研究确定了许多与甲状腺功能相关的化学生物标志物,特别是在混合暴露场景中.
- 化学混合物,包括农药,金属和特定的有机化合物,在不同年龄段影响甲状腺功能.
- 这些发现强调了在环境健康研究和政策中考虑化学混合物的重要性.
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