睡眠可能是大脑/认知/神经储备建设因素吗? 在动物模型中对睡眠调节的认知影响进行系统审查
Francesca Balsamo1, Debora Meneo2, Erica Berretta3
1Department of Human Sciences, Guglielmo Marconi University, Rome 00193, Italy; IRCCS Fondazione Santa Lucia, Rome 00179, Italy.
Neuroscience and biobehavioral reviews
|January 19, 2025
概括
充足的睡眠增强了大脑的弹性和认知储备,防止与年龄相关的衰退. 睡眠不足显著损害认知功能,特别是记忆力,强调睡眠对大脑健康的关键作用.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 睡眠研究 睡眠研究
背景情况:
- 大脑/认知/神经储备概念认为,终身经验可以增强大脑对损伤的弹性.
- 睡眠等可改变的因素可以增强这种储备,抵消与年龄或疾病相关的认知变化.
- 睡眠障碍与神经退行性风险增加有关,并影响认知功能.
研究的目的:
- 系统地审查功能性和睡眠障碍如何影响动物的认知功能和神经形态机制.
- 阐明睡眠在大脑/认知/神经储备的发展和调节中的作用.
主要方法:
- 在PROSPERO (ID:CRD42023423901) 登记的系统审查,遵循PRISMA-P指南.
- 在PubMed,Scopus,Web of Science和Embase数据库中搜索到2022年6月.
- 包括关于睡眠,动物和认知功能的研究,分析了28666篇识别文章中的142篇.
主要成果:
- 睡眠不足导致动物的认知能力显著下降,尤其是记忆能力.
- 有证据表明,睡眠质量和认知功能维护之间存在强烈联系.
- 睡眠障碍的神经形态影响也被观察到.
结论:
- 睡眠是调节大脑/认知/神经储备的一个关键因素.
- 保持健康的睡眠模式对于终身认知性至关重要.
- 动物模型为睡眠在认知储备中的作用提供了宝贵的洞察力,可以了解睡眠在认知储备中的作用背后的神经生物学机制.
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