血清维生素D与非酒精性脂肪肝疾病中抑郁症之间的关联
Rong Jiang1,2, Manman Lu3, Yunfeng Hua1
1Department of Clinical Medicine, Jiangsu Health Vocational College, Nanjing, China.
Asia Pacific journal of clinical nutrition
|January 19, 2025
概括
较高的维生素D水平可能会降低非酒精性脂肪肝 (NAFLD) 患者的抑郁风险. 这种保护作用在男性和患有NAFLD的肥胖个体中尤其明显.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 精神病学是一个精神病学.
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一种普遍存在的疾病,可能与精神健康障碍有关.
- 以前的研究表明,血清维生素D与NAFLD抑郁症之间存在相关性,但研究结果不一致.
- 准确诊断NAFLD和抑郁症对于理解这种关系至关重要.
研究的目的:
- 为了研究血清维生素D水平与被诊断为NAFLD的个体的抑郁症之间的关联.
- 为了澄清在NAFLD人口中维生素D状况和抑郁症状之间的有争议的联系.
- 在这项研究中,利用过渡性弹性学来准确诊断NAFLD.
主要方法:
- 对NHANES 2017-2018数据集的横截面分析.
- 使用患者健康问卷-9 (PHQ-9) 评分 (≥10) 的抑郁症评估.
- 通过振动控制的短暂弹性成像 (VCTE) 诊断NAFLD;使用样本重量的二进制逻辑回归进行统计分析.
主要成果:
- 分析了1339名NAFLD参与者;8.58%的人患有抑郁症.
- 血清维生素D水平升高是NAFLD患者抑郁症的重要保护因素 (OR=0.61,p=0.048).
- 这种关联在男性 (OR=0.32,p=0.024) 和肥胖个体 (OR=0.53,p=0.019) 中更为强烈.
结论:
- 血清维生素D的增加与NAFLD的抑郁症患病率有负面关联.
- 这些发现强调了维生素D的保护作用,特别是在男性和肥胖的NAFLD人群中.
- 经VCTE确认的NAFLD病例显示了维生素D和抑郁症之间的显著反向关系.
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