维尼克脑病症呈现出混乱和听力损失
Lucy Carson1, Munashe Veremu2, Aaron Jesuthasan2
1Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK lucy.carson@nhs.net.
BMJ case reports
|January 19, 2025
概括
这项案例研究突出了在病史不典型的患者身上发生的韦尼克脑病 (WE). 早期诊断和治疗至关重要,尽管仍可能出现Korsakoff综合征的进展.
科学领域:
- 神经学 神经学
- 神经科学是一个神经科学.
- 内部医学 内部医学
背景情况:
- 韦尼克脑病 (Wernicke's encephalopathy,简称WE) 是一种严重的神经疾病,通常与胺缺乏有关.
- 经典的症状包括混乱,缺氧和眼,但表现可能有所不同.
- 准确的诊断对于及时干预和预防不可逆转的神经损伤至关重要.
研究的目的:
- 介绍一个患有韦尼克脑病的病例,最初不清楚酒精史.
- 讨论差异诊断以及在疑似WE病例中重新评估患者病史的重要性.
- 突出WE特征的神经成像发现及其潜在的进展.
主要方法:
- 一个50多岁的男性患者的病例报告显示,他出现了WE症状.
- 临床评估包括神经学检查和详细的病史.
- 神经成像 (T2/FLAIR MRI) 用于识别特征性脑损伤.
主要成果:
- 患者表现出失方向,步态,垂直阴影,听力损失和前级失忆症.
- 神经成像证实了中介性丘脑中对称的T2/FLAIR高强度,这是WE的标志.
- 尽管最初情况有所改善,但患者的病情进展为Korsakoff综合征,残留失忆症和语.
结论:
- 维尼克脑病变可能出现不典型的病史,需要进行彻底的诊断评估.
- 重新检查患者病史和利用神经成像对于诊断WE至关重要.
- 早期治疗可能会改善一些症状,但可能导致Korsakoff综合征的进展,需要认知康复.
相关概念视频
01:10Higher Mental Functions of the Brain: Language
726
Language is a system of communication that allows the expression of thoughts, ideas, and feelings. The brain processes language in both hemispheres.
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
Language formation and comprehension take place in the dominant hemisphere. The dominant hemisphere is responsible for understanding the meaning of spoken, written, or sign language, as well as the ability to communicate. For most people, the left hemisphere is the dominant one. The right hemisphere, then, gives tone and emotional context to the...
726
01:31Hearing
51.8K
When we hear a sound, our nervous system is detecting sound waves—pressure waves of mechanical energy traveling through a medium. The frequency of the wave is perceived as pitch, while the amplitude is perceived as loudness.
51.8K
01:13Amnesia
99
Amnesia is a condition marked by long-term memory loss, which impairs the ability to recall past events or create new memories.
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
The severity and duration of memory loss vary depending on the type and underlying cause. Amnesia is classified into two main types: retrograde and anterograde.
Retrograde amnesia is marked by the loss of memories formed before the onset of the condition. Patients may recall distant past events but often forget those occurring shortly before the incident.
Anterograde...
99
01:13The Cochlea
44.5K
The cochlea is a coiled structure in the inner ear that contains hair cells—the sensory receptors of the auditory system. Sound waves are transmitted to the cochlea by small bones attached to the eardrum called the ossicles, which vibrate the oval window that leads to the inner ear. This causes fluid in the chambers of the cochlea to move, vibrating the basilar membrane.
44.5K
01:29Pneumonia II: Pathophysiology
212
The pathophysiology of pneumonia involves the following steps:
212
01:30Dementia
93
Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
The progression of dementia is generally gradual....
93