神经内分泌瘤的胰腺切除后的理想结果:全国性的研究
Jeffrey W Chen1, Simone A Augustinus2, Bert A Bonsing3
1Amsterdam UMC, Location University of Amsterdam, Department of Surgery, Amsterdam, the Netherlands; Cancer Center Amsterdam, Amsterdam, the Netherlands; Amsterdam Center for Endocrine and Neuroendocrine Tumors (ACcENT), Amsterdam, the Netherlands.
概括
胰腺神经内分泌瘤 (pNET) 切除的理想结果低于胰腺管道腺癌 (PDAC) 切除,这主要是由于胰腺瘤切除术后胰腺瘤 (POPF) 发生率较高.
科学领域:
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
- 临床结果研究研究
背景情况:
- 胰腺神经内分泌瘤 (pNET) 的胰腺切除可能比胰腺导管腺癌 (PDAC) 的并发症率更高.
- 新的复合"理想结果"测量方法全面评估术后康复.
研究的目的:
- 为了确定pNET.NET的胰腺切除后的"理想结果"率.
- 为了将这些比率与PDAC切除后的比率进行比较.
主要方法:
- 一项观察性队列研究利用了来自荷兰胰腺癌审计 (2014-2021) 的全国数据.
- 包括的患者接受了针对pNET或PDAC的胰腺切除.
- 理想结果被定义为没有死亡率,B级/C级的术后胰腺抽 (POPF),严重并发症,长时间停留,重新手术和再入院.
主要成果:
- 分析了524个pNET和2851个PDAC切除.
- 与PDAC (55.7%) (P<0.001) 相比,pNET (47.7%) 的理想结局率较低.
- 这种差异是由胰腺二切除术驱动的,在pNET患者中,POPF的发生率显著更高 (32.1%vs7.9%).
结论:
- 与PDAC相比,对于pNET的胰腺二切除术与理想结果的减少有关.
- 增加四倍的POPF风险显著影响了接受胰腺二切除术的PNET患者的结果.
- 强调需要针对pNET的患者咨询和POPF缓解策略.
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