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液晶网络阻碍了癌细胞的恶性发展

Daniele Martella^1,2, Ignazia Tusa³, Alessandro Tubita³

¹Department of Chemistry "Ugo Schiff", University of Florence, via della Lastruccia 3-13, Sesto Fiorentino, 50019, Italy.

Advanced healthcare materials

|January 19, 2025

概括

合成液晶网络 (LCN) 降低了转移性黑色素瘤细胞的生长,并促进了向不那么恶性上皮表皮类型的转变. 这些发现表明LCNs是潜在的抗癌涂层,没有额外的刺激.

科学领域:

生物材料科学生物材料科学
癌症生物学癌症生物学
材料化学材料化学

背景情况:

细胞外矩阵 (ECM) 仿真对体外癌症模型和治疗开发至关重要.
调节癌细胞生物学和减少恶性瘤的合成材料尚未得到充分研究.
液晶网络 (LCN) 为生物材料应用提供了独特的特性.

研究的目的:

评估基于LCN的支架对A375转移性黑色素瘤细胞生长的影响.
研究由LCNs诱导的潜在细胞机制.
探索LCNs作为抗癌涂料的潜力.

主要方法:

在LCN支架上培养A375转移性黑色素瘤细胞,具有不同度的交叉连接器.
评估细胞增殖和殖民地形成能力.
使用显微镜和分子标记器分析细胞衰老和表型.
研究物质-细胞相互作用在诱导生物变化的作用.

主要成果:

与标准板相比,LCN支架显著降低了黑色素瘤细胞的增殖和殖民地形成.
在LCNs上的细胞表现出增长的衰老和转向表皮表型的转变,这表明介质细胞到表皮细胞的过渡 (MET).
观察到的效应取决于LCN材料中的交叉连接剂含量.
生物学结果仅由基质相互作用引起,没有外部化学或物理刺激.

结论:

基于LCN的支架可以在体外有效地抑制黑色素瘤细胞生长和恶性瘤.
观察到的抗癌作用是由特定物质的相互作用介导的,促进衰老和MET.
液态色素是开发新型抗癌涂料和治疗策略的有前途的平台.

关键词:

A375 黑色素瘤细胞癌症癌症癌症癌症癌症细胞衰老细胞衰老液晶网络是液晶网络中的一个.光聚合的光聚合方式.聚合物细胞支架的架构.瘤的攻击性瘤的攻击性

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