来自acrorus tatarinowii的活性成分对精子及其分子机制的保护作用
Zonglin Lu1,2, Haiyang Zhao3,4, Hui Wang4
1The Second Clinical Medical College, Henan University of Traditional Chinese Medicine, No. 7, Jiudu Road, Xigong District, Zhengzhou, Henan, 450008, China. 13721627607@163.com.
Basic and clinical andrology
|January 19, 2025
概括
Acrorus tatarinowii显示出治疗男性不孕症的治疗潜力,具体来说是橄酸精. 它可以通过调节BCL2/Bax/Caspase3通路和减少亡来改善精子功能.
科学领域:
- 生殖生物学 生殖生物学
- 传统中国医药 传统中国医药
- 分子药理学分子药理学
背景情况:
- 以低精子数量和运动性为特征的Oligoasthenozoospermia是男性不孕症的重要原因之一.
- BCL2/Bax/Caspase3信号通路在调节亡中起着至关重要的作用,影响精子生成.
- 阿克罗鲁斯塔塔里诺维 (Acrorus tatarinowii) 是一种具有潜在药用功能的传统草药.
研究的目的:
- 为了评估Acrorus tatarinowii在治疗精症时的治疗效果.
- 阐明Acrorus tatarinowii的潜在机制,重点关注其对BCL2/Bax/Caspase3通路的调制.
主要方法:
- 使用TCMSP和Disgenet数据库识别Acrorus tatarinowii的活性化合物和目标基因.
- 诱导一个小鼠模型的oligoasthenozoospermia和随后的治疗与Acrorus tatarinowii.
- 评估血清激素水平 (ELISA),丸组织病理学 (HE染色) 和基因表达 (qPCR,西式斑点).
主要成果:
- 用Acrorus tatarinowii治疗显著上调BCL2表达在oligoasthenozoospermic大鼠的丸.
- 在丸组织中观察到自身病理学的改善.
- 治疗后血清中素激素 (LH) 和卵泡刺激激素 (FSH) 的水平有所降低.
结论:
- Acrorus tatarinowii通过调节BCL2/Bax/Caspase3通路,证明了在橄酸类动物精子症中具有治疗效果.
- 草本可以通过抑制细胞灭绝和促进生殖细胞的增殖来发挥其益处.
- Acrorus tatarinowii具有作为男性不孕症与精子功能障碍相关的天然治疗剂的潜力.
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