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Updated: Jun 1, 2025

Analyzing and Building Nucleic Acid Structures with 3DNA
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Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

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对人类拓酶3βDNA和RNA催化和核酸门动态的结构见解

Xi Yang1, Xuemin Chen2,3, Wei Yang4

  • 1Developmental Therapeutics Branch & Laboratory of Molecular Pharmacology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.

Nature communications
|January 19, 2025
PubMed
概括

人类拓聚酶III-β (TOP3B) 能分解DNA/RNA结构,并有助于mRNA的翻译. 低温-EM结构揭示了其催化循环和链穿越机制,使其与仅含DNA的拓聚酶III-α (TOP3A) 不同.

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