在母乳养期间重新登上ART:一个未解决的问题
Chiara Dallagiovanna1, Giorgia Di Stefano2, Marco Reschini2
1Infertility Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via M. Fanti, 6, 20122, Milan, Italy. chiara.dallagiovanna@policlinico.mi.it.
Archives of gynecology and obstetrics
|January 19, 2025
概括
在母乳养期间接受辅助生殖技术 (ART) 的女性可能因荷尔蒙变化而面临挑战. 虽然证据有限,但推迟ART直到停止母乳养后,通常建议获得最佳结果.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 不孕症治疗 不孕症治疗
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 追求生育治疗的妇女在母乳养期间可以寻求辅助生殖技术 (ART).
- 哺乳诱导激素变化 (益生素,催产素),可能会影响生殖生理学.
- 关于哺乳期的ART安全性和有效性的有限的有力的证据存在.
研究的目的:
- 审查现有的关于母乳养对ART结果影响的文献.
- 确定哺乳期ART对母婴健康的潜在不良影响.
- 为临床医生和患者提供关于母乳养期间ART的指导.
主要方法:
- 一个关于相关科学文献的叙事评论.
- 专注于研究母乳养对卵巢功能,子宫受容性和胚胎发育的荷尔蒙影响.
- 在ART周期中使用外源激素的潜在风险.
主要成果:
- 哺乳可能会对排卵,卵泡发育,子宫收缩性和早期胚胎发育产生负面影响.
- 对卵巢刺激周期的担忧最大,其次是自然周期胚胎移植,然后是激素替代治疗周期.
- 外源激素对婴儿健康的潜在风险主要与刺激周期有关.
结论:
- 虽然证据不足以完全拒绝母乳养期间的ART接入,但通常建议推迟治疗直到停止.
- 本建议考虑了对ART成功的潜在不良影响以及短暂的妊娠间隔的风险.
- 寻求更早获得ART的妇女必须充分了解不完全令人放心的证据和潜在风险.
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