超弹性构成模型的健康和酶介导退化的关节软骨
Asif Istiak1, Saiful Islam1, Malek Adouni2
1Department of Mechanical Engineering, University of Louisiana at Lafayette, Lafayette, LA, 70503, USA.
Biomechanics and modeling in mechanobiology
|January 19, 2025
概括
本研究提出了一种曲线拟合方法,用于确定健康和退化的软骨的超弹性模型参数,以帮助有限元分析. 第二阶缩小多项式和范德瓦尔斯模型最适合软骨力学,显示与矩阵金属蛋白酶水平相关的参数变化.
科学领域:
- 生物材料科学 生物材料科学
- 计算力学 计算力学 计算力学
- 生物化学 生物化学
背景情况:
- 软骨退化,通常是由于矩阵金属蛋白酶 (MMPs),损害了关节功能.
- 了解软骨机制对于开发有效的治疗方法和计算模型至关重要.
- 酶降解显著改变了细胞外基质 (ECM) 和软骨的机械特性.
研究的目的:
- 为健康和退化软骨的超弹性构成模型开发一个系统的曲线合适方法.
- 评估各种超弹性模型的捕捉MMP介导的软骨退化能力.
- 为了将材料参数的变化与特定MMPs (MMP-1和MMP-9) 的丰度相关联.
主要方法:
- 压力-应变数据的系统曲线拟合从缩试验.
- 现象学超弹性构成模型的应用:奥格登,多项式,缩小多项式和范德瓦尔斯.
- 优化每个模型的材料常数,以适应健康和酶降解软骨的实验数据.
主要成果:
- 第二阶缩小多项式和范德瓦尔斯模型证明最适合实验压力-应变数据.
- 材料系数,特别是剪模系数,随着酶降解的增加而下降.
- 模型系数的减少与MMP-1和MMP-9的相对丰度有差异的相关性,这表明退化程度的严重程度.
结论:
- 开发的曲线拟合方法有效量化了退化的软骨的超弹性参数.
- 第二阶缩小多项式和范德瓦尔斯模型适用于模拟MMP介导的软骨退化.
- 这项研究提供了MMPs对软骨力学和退化生物化学影响的见解.
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