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相关概念视频

Phagocytosis of Apoptotic Cells01:17

Phagocytosis of Apoptotic Cells

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Cells undergoing apoptosis form apoptotic bodies that must be removed immediately to prevent inflammation, autoimmune diseases, and necrosis. Phagocytosis is carried out by professional phagocytes such as macrophages or  immature dendritic cells. Non-professional phagocytes such as  epithelial cells and fibroblasts also take part in this process; however, they are not as effective as professional phagocytes. 
Normal cells contain receptors that prevent them from being recognized...
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The Extrinsic Apoptotic Pathway01:17

The Extrinsic Apoptotic Pathway

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The extrinsic apoptotic pathway is initiated when extracellular death-inducing signals, such as specific cytokines, activate the death receptors expressed on the cell surface. The immune cells involved in this pathway are natural killer cells (NK cells) and cytotoxic T-lymphocytes. NK cells are critical in innate immune response, while cytotoxic T-lymphocytes are associated with adaptive immune response. These cells recognize specific receptors expressed on the altered cells and activate...
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Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

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The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
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Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

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Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
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相关实验视频

Updated: Jun 1, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

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表达CD11c的微质是暂时的,由与亡细胞的相互作用驱动.

Nathaniel Ghena1,2, Sarah R Anderson1, Jacqueline M Roberts1

  • 1Department of Neurobiology, University of Utah School of Medicine, Salt Lake City, Utah, USA.

Glia
|January 20, 2025
PubMed
概括

CD11c+微质是视网膜发育中的一个临时状态,而不是一个独特的子集. 这些细胞有助于清除亡神经元,但对细胞形成无关紧要.

关键词:
在CD11c中,CD11c是指CD11c.发展发展发展发展发展.微质细胞中的微质细胞神经元的亡是神经元的亡.发酵细胞的形成 发酵细胞的形成

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In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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相关实验视频

Last Updated: Jun 1, 2025

Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility
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Rapid and Refined CD11b Magnetic Isolation of Primary Microglia with Enhanced Purity and Versatility

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In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 发展生物学 发展生物学

背景情况:

  • 微质细胞,大脑的免疫细胞,在发育过程中发挥着不同的作用.
  • 微质表现出转录异质性,表明了专门的功能.
  • 微质状态的动态性质和调节仍然不太清楚.

研究的目的:

  • 为了研究CD11c+微质在成长中的视网膜中的调节和功能.
  • 为了确定CD11c+微是否代表一个专门的子集或一个暂时的状态.

主要方法:

  • 在产后视网膜微质中对CD11c表达的分析.
  • 基因命运映射用于跟踪微质状态转换.
  • 选择性切除CD11c+微质细胞以评估功能影响.

主要成果:

  • CD11c+微质细胞与神经元亡的波浪相关.
  • 这些微质细胞呈现出增加的溶解体含量,并参与细胞缩的细胞清除.
  • CD11c表达部分受到TAM受体AXL的调节.
  • CD11c+微质细胞并不是唯一对细胞清除至关重要的.

结论:

  • CD11c+微质体代表一种由发育性亡引起的过渡性功能状态.
  • 这种状态是动态的,微质细胞回到平衡状态.
  • CD11c表达是对亡残留物暂时反应的标记,而不是专门的细胞子集.