在接受干细胞调动的患者中,plerixafor对静血系统的影响
Özge Koç1, Özlem Doğan2, Uğur Şahin3
1Department of Internal Medicine, Ankara University School of Medicine, Ankara, Turkey.
Hematology/oncology and stem cell therapy
|January 20, 2025
概括
普莱里克萨福与G-CSF一起用于干细胞调动的普莱里克萨福不会显著增加血液凝固风险. 这项研究发现,当plerixafor被添加到G-CSF治疗中时,没有额外的促凝效应.
科学领域:
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 已知颗粒细胞殖民地刺激因子 (G-CSF) 影响血静.
- 普雷里克萨福尔对静血系统的影响需要进一步澄清,特别是在自主干细胞调动 (ASCM) 的背景下.
研究的目的:
- 评估plerixafor在淋巴瘤和多发性骨髓瘤患者的ASCM期间对血液静止系统的影响.
- 为了比较G-CSF单独与G-CSF加plerixafor调动的患者之间的静血参数.
主要方法:
- 接受ASCM的患者的潜在招募.
- 血液样本采集在预动员和预非瑞斯之前,用于分析CBC,凝血测试,CRP,蛋白C和S,vWF抗原以及XVIII和XII因子.
- 在A群 (G-CSF) 和B群 (G-CSF + plerixafor) 之间的比较.
主要成果:
- 单独的G-CSF (A队列) 增加了VIII因子,INR,vWF抗原和CRP,同时降低了蛋白C和S.
- 相比之下,G-CSF加上plerixafor (B队列) 在凝血参数或蛋白C和S水平上没有显著变化.
- 在B队列中,在plerixafor给药后观察到纤维素素的轻微减少.
结论:
- 将plerixafor添加到ASCM的G-CSF中并没有诱导进一步显著的促凝效应.
- 在与G-CSF结合用于干细胞调动时,plerixafor似乎对静血变化是安全的.
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