结肠维生素D受体和炎症性肠病:与组织学或内镜炎症没有相关性
Harald Bagger-Jörgensen1,2, Christian Thomsen3,4, Martine Borrisholt3,4
1Department of Clinical Sciences, Malmö, Lund University, Malmö, Sweden.
概括
维生素D受体 (VDR) 在肠道中的表达不会随着炎症性肠病 (IBD) 活动而改变. 这项研究发现VDR水平与IBD严重程度或对照之间没有显著的相关性.
科学领域:
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 维生素D受体 (VDR) 在炎症性肠病 (IBD) 发病过程中的作用尚不清楚.
- 现有研究表明,IBD患者的VDR表达与不一致的发现.
研究的目的:
- 调查IBD患者免疫组织化学VDR表达和疾病活性之间的关系.
- 为了比较活跃IBD与非活跃IBD中的VDR表达,以及IBD患者和非IBD对照者之间的IBD表达.
主要方法:
- 在28名IBD患者 (性结肠炎和克罗恩病) 和12名对照患者的肠道活检中对VDR表达的免疫组织化学分析.
- 对VDR表达与组织学炎症的相关性分析,结肠镜检查结果,临床参数和血清维生素D水平.
主要成果:
- 在表皮或肌区间中,VDR表达水平在活性和非活性IBD之间没有显著差异.
- 没有观察到VDR表达与组织学炎症,结肠镜外观或临床/实验室测量,包括血清25(OH) 维生素D之间的显著相关性.
- 一个趋势表明,与IBD患者相比,对照组的VDR表达较高,尽管这没有达到统计学意义.
结论:
- IBD 疾病活性与 VDR 免疫组织化学表达没有相关性.
- 在肠道活检中,VDR表达水平在IBD患者和对照人群之间没有显著差异.
- 需要进一步的前性研究来探索IBD中的VDR活性及其与对照者的关系.
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