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表观遗传衰老和心房阻塞之间的关联:一个双样本的门德尔随机化研究

Wanqian Pan¹, Chi Zhang¹, Xiaojiao Du¹

¹Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, P. R. China.

|January 20, 2025

概括

通过GrimAge加速来衡量表观遗传衰老,与心房阻塞 (AVB) 的风险增加有关. 这一发现凸显了表观遗传衰老在AVB预防策略中的重要性.

科学领域:

心血管表观遗传学心血管表观遗传学
遗传流行病学遗传流行病学
衰老研究研究衰老研究

背景情况:

心房静脉阻塞 (AVB) 是一种常见的心律障碍.
表观遗传衰老,反映生物年龄,越来越多地被认为是疾病风险的一个因素.
了解表观遗传衰老和AVB之间的因果关系对于预防至关重要.

研究的目的:

调查表观遗传衰老对心脏静脉阻塞 (AVB) 患病率的因果关系.
使用孟德尔随机化 (MR) 分析来评估对表观遗传衰老和AVB的遗传倾向.
探索表观遗传衰老和AVB之间的因果关系的方向性.

主要方法:

孟德尔随机化 (MR) 分析是使用基因仪器用于表观遗传衰老 (GrimAge加速) 和AVB.
数据来源于爱丁堡数据共享和FinnGen生物库中的全基因组关联研究.
进行了单变量,多变量和灵敏度分析,以确保可靠的发现.

主要成果:

基因预测的GrimAge加速与AVB风险增加显著相关 (IVW:p=0.010,95%CI=1.024-1.196;加权中位数:p=0.031,95%CI=1.009-1.215).
没有证据支持AVB对表观遗传衰老的因果关系.
多变量MR分析,调整风险因素,证实了表观遗传衰老和AVB之间的联系.

结论:

表观遗传衰老,特别是GrimAge加速,可能会因果性地增加发展心房静脉阻塞 (AVB) 的风险.
这些发现强调了针对表观遗传衰老在预防AVB方面的潜在作用.
进一步研究将表观遗传衰老与AVB联系在一起的机制是有必要的.

关键词:

在心房房阻塞.通过DNA甲基化.门德尔的随机化生物衰老生物衰老表观遗传衰老表观遗传衰老老年病学老年病学是一门学科.

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