简单的和绿色的过程,用于丝纤维素生产通过水脱皮
Ipek Atay1, Ecenaz Asad1, M Baris Yagci2
1Chemistry Department, Koc University, Sariyer, Istanbul 34450, Turkey.
ACS omega
|January 20, 2025
概括
一种新的绿水脱方法有效地从丝纤维素 (SF) 中去除素,简化了用于组织工程的支架生产. 这种环保的过程提高了生物材料中的细胞活力.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 绿色化学 绿色化学
背景情况:
- 丝纤维素 (SF) 是用于组织工程支架的有希望的生物相容材料.
- 传统的谢里去除和SF溶解方法使用强化学品和广泛的净化,可能损害SF特性.
- 需要可持续和高效的SF加工方法.
研究的目的:
- 开发一种简单,绿色和高效的基于水的丝纤维素 (SF) 脱皮方法.
- 用环保酸混合物研究SF的溶解.
- 为了评估加工的SF对生物材料混合物的细胞活力的影响.
主要方法:
- 一种使用沸水去除素的新水脱技术.
- 使用酸/酸混合物溶解SF.
- 制造电聚 (乳酸) /SF混合物和细胞活性的评估.
主要成果:
- 使用沸水,在6小时内几乎完全清除了血清素 (体重30%).
- 成功地将SF溶解在环保的酸混合物中,消除了对强烈盐和透析的需求.
- 与对照组相比,在聚乳酸/SF混合物中显著提高了细胞活力.
结论:
- 水脱皮是一种简单,绿色和有效的方法,用于生产用于组织工程的丝纤维蛋白.
- 开发的过程简化了SF净化,并保留了其性能.
- 这种环保的方法有助于创建具有改善细胞兼容性的生物活性支架.
相关概念视频
Types of Step-Growth Polymers: Polyesters
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
Upstream Processing
Upstream processing represents a critical phase in biomanufacturing, wherein biological systems such as microorganisms, mammalian cells, or insect cells are cultivated to produce therapeutic proteins, vaccines, enzymes, or other biologically derived products. This phase encompasses all steps from the selection and genetic manipulation of the production organism to the cultivation of cells in bioreactors under tightly controlled environmental conditions.Host Selection and Genetic OptimizationThe...
Production of Alcohol
Continuous fermentation is a key strategy in industrial ethanol production, particularly when efficiency, scalability, and high yields are essential. This approach allows for uninterrupted operation and optimized resource utilization. The primary feedstock, corn starch, undergoes enzymatic hydrolysis facilitated by α-amylase and glucoamylase. These enzymes break down the starch into fermentable sugars such as glucose, which are readily assimilated by fermentative microorganisms.Fermentation...
Production of Organic Acids
Lactic acid, an important organic acid extensively applied in food, pharmaceutical, and biodegradable polymer industries, is primarily produced via microbial fermentation. This method is favored over chemical synthesis due to its environmental sustainability and capacity for enantiomerically pure product formation. Among various microbial processes, the fermentation of starch-based substrates stands out due to the abundance and renewability of raw materials like corn and potatoes.Hydrolysis of...
Biological Treatment of Effluent and Waste Water
Biological wastewater treatment relies on the metabolic activity of microorganisms to remove pollutants from sewage. In modern treatment systems, this process is organized into sequential stages that progressively reduce solid material, dissolved organic matter, and microbial contamination. Each stage plays a distinct role in improving water quality and preparing the effluent for safe discharge or reuse.Primary and Secondary TreatmentPrimary treatment is a physical process that removes large...
Downstream Processing
Downstream processing begins once fermentation is complete and involves a series of steps to recover and purify products such as acids, vitamins, antibiotics, or proteins.Cell HarvestingFor example, for intracellular protein-based products, the first step is harvesting the cells. This is typically achieved using centrifugation or filtration to separate the cells from the liquid phase.Cell Disruption for Intracellular ProductsIf the target product is intracellular, the harvested cells must be...


