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Updated: Jun 1, 2025

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符合形态限制的Grp94-选择性抑制剂

Hao Xu1, Kyler Pugh1, Brian S J Blagg1

  • 1Department of Chemistry and Biochemistry, Warren Center for Drug Discovery, The University of Notre Dame, 305 McCourtney Hall, Notre Dame, Indiana 46556, United States.

ACS omega
|January 20, 2025
PubMed
概括

研究人员通过修改KUNG65.5开发了新的Grp94抑制剂. 化合物C6选择性地结合Grp94,显示出治疗癌症和玻璃眼等疾病的前景.

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Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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