作为多克索鲁比的药物输送系统,应用基于氨酸的氧反应性器官凝
Diba Zare1, Gamze Yılmaz1, Salih Özçubukçu1
1Department of Chemistry, Middle East Technical University, 06800 Ankara, Turkey.
ACS omega
|January 20, 2025
概括
由氨酸衍生物制成的对氧化还原反应有机体,在对谷氨 (GSH) 的反应中释放药物. 这表明使用这些GSH响应性药物递送系统有针对性癌症治疗的潜力.
科学领域:
- 生物材料科学 生物材料科学
- 药物输送系统 药物输送系统
- 癌症治疗 癌症治疗
背景情况:
- 带有二硫化键的氨酸衍生物作为氧化还原反应器官受体.
- 癌细胞中的高谷氨水平使得向药物可被提供.
- 谷氨 (GSH) 是细胞氧化还原平衡中至关重要的三.
研究的目的:
- 为了研究l-Cys(t-dodecyl-sulfanyl) -OH和l-Cys-(StBu) -OH基有机凝的药物传递能力.
- 为了评估这些器官凝的GSH反应性药物释放特性.
- 评估体外生物相容性,并描述器官受体器官的纳米结构.
主要方法:
- 使用TEM,XRD,FTIR和风湿学进行器官凝形成和表征.
- 在谷氨 (GSH) 的存在下进行药物释放研究.
- 在L929细胞上使用MTT试验进行体外细胞毒性评估.
主要成果:
- 机体凝器通过键和范德瓦尔斯相互作用形成纳米纤维.
- 在GSH的存在下,多克索鲁比成功地从器官凝中释放出来.
- l-Cys-(StBu) -OH没有显著的毒性,而l-Cys(t-dodecyl-sulfanyl) -OH对L929细胞的毒性较低.
结论:
- 基于氨酸的有机凝是有效的氧化还原反应药物递送系统.
- 由于GSH的响应性,这些器官凝显示出针对性癌症治疗的潜力.
- 开发的器官凝聚器表现出适用于生物医学应用的良好生物相容性.
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