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Updated: Jun 1, 2025

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合成β-d-Glucuronides:用于探索人类肠道细菌降解葡萄胺的基质

Aleksandra Gorecka1, Heidi Schacht2, Megan K Fraser1

  • 1Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, U.K.

ACS omega
|January 20, 2025
PubMed
概括

研究人员合成了新的葡萄糖化物模型基质,以研究人类肠道微生物群 (HGM) 酶. 这些工具揭示了化合物及其葡萄化物对细菌生长和宿主健康的明显影响.

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Glucuronidation, a pivotal phase II biotransformation process, involves the coupling of glucuronic acid to a drug or xenobiotic. Given its widespread occurrence and critical role in drug metabolism, it's considered the most crucial phase II reaction. It enhances the water solubility of substances, aiding their expulsion from the body. The driving force behind these reactions is a group of enzymes known as UDP-glucuronosyltransferases (UGTs). UGTs facilitate the transfer of a glucuronic acid...
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α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
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