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Updated: Jul 31, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

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理性设计和优化一个强大的IDO1蛋白解向的奇米拉 (PROTAC)

Paige J Monsen, Prashant V Bommi, Arabela A Grigorescu

    bioRxiv : the preprint server for biology
    |January 20, 2025
    PubMed
    概括

    一种新型的PROTAC,NU227326,在质母细胞瘤细胞中有效降解胺2,3-二氧化酶1 (IDO1). 这种向降解为癌症免疫治疗提供了一个有希望的新策略,通过中和IDO1来实现免疫治疗.

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    Author Spotlight: Evaluating Biophysical Assays for Characterizing PROTACS Ternary Complexes

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    Because the DNA segments are cut and reorganized in a direction-specific manner, site-specific recombination has emerged as an efficient genetic engineering technique. Flippase and Cyclization recombinases or Flp and Cre, respectively, are two members of the tyrosine recombinase family derived from bacteriophages, that are used to mediate site-specific DNA insertions, deletions, and targeted expression of proteins in mammalian cell lines.
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