适应,而不是预测,驱动哺乳动物感官皮层中神经元尖端反应
Jacob A Westerberg1,2, Yihan S Xiong1, Hamed Nejat1
1Department of Psychology, Vanderbilt Brain Institute, Vanderbilt Vision Research Center, Vanderbilt University, Nashville, Tennessee, United States.
bioRxiv : the preprint server for biology
|January 20, 2025
概括
大脑预测编码 (PC) 理论表明,预测错误会信号出意想不到的刺激. 这项研究发现,真正的预测错误,挑战PC,仅限于高阶大脑区域,而不是早期的感官处理.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 认知科学 认知科学
背景情况:
- 预测编码 (PC) 理论认为大脑产生内部模型来预测事件.
- 预想不到的刺激被认为会产生通过大脑传播的预测错误.
- 将真正的预测错误与适应区分开来,需要仔细的实验设计.
研究的目的:
- 用视觉奇怪的范式来测试预测编码假设.
- 在视觉层次结构中调查预测错误的神经基础.
- 为了区分对本地和全球奇怪球的反应,以隔离真正的预测错误.
主要方法:
- 在老鼠和子中,在视觉层次结构中记录了神经元尖端活动.
- 采用了一个视觉奇怪任务,以当地和全球的奇怪人物为特色.
- 分析的重点是神经对不同奇怪类型的反应的时间和位置.
主要成果:
- 当地奇怪的反应与预测编码保持一致:早期,强大和前.
- 全球奇怪的反应,表明真正的预测错误,在早期的视觉区域是弱的和不频繁的.
- 在前额叶皮层等更高阶区域观察到更强的全球奇怪反应.
结论:
- 真正的预测编码不会在感官处理的早期出现,这与标准PC模型相反.
- 预测编码机制似乎只适用于更高阶的认知大脑区域.
- 这些发现完善了我们对大脑如何处理预测错误和更新内部模型的理解.
相关概念视频
The Role of Ion Channels in Neuronal Computation
3.1K
A postsynaptic neuron usually receives numerous impulses from several other presynaptic neurons. The axon hillock of the postsynaptic neuron integrates all these signals and determines the likelihood of firing an action potential.
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
Sometimes a single EPSP is strong enough to induce an action potential in the postsynaptic neuron. However, multiple presynaptic inputs must often create EPSPs around the same time for the postsynaptic neuron to be sufficiently depolarized to fire an action potential....
3.1K
Somatosensation
36.4K
The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.
36.4K
Neuroplasticity
281
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
281
Somatosensory, Motor, and Association Cortex
391
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
391
Action Potential
7.7K
Neurons communicate by firing action potentials—the electrochemical signal that is propagated along the axon. The signal results in the release of neurotransmitters at axon terminals, thereby transmitting information to the nervous system. An action potential is a specific "all-or-none" change in membrane potential that results in a rapid spike in voltage.
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
Membrane potential in neurons
Neurons typically have a resting membrane potential of about -70 millivolts (mV). When they...
7.7K


